genomic instabilities การใช้

• Fundamentally, mutations in caretaker genes lead to genomic instability.
• Research suggests that genomic instability affects the cancer cells ability to metastasize.
• His research interests include studying genomic instability in aging.
• These regions are prime sites to display genomic instability.
• Loss of p53 creates genomic instability that most often results in an aneuploidy phenotype.
• Sometimes called EEs, extrachromosomal elements, have been associated with genomic instability in eukaryotes.
• Chromosomal rearrangements causing genomic instability are found in the cells of Rothmund-Thomson syndrome patients.
• Overall, it seems that oxidative stress is a major cause of genomic instability in the brain.
• This generates genomic instability through increased inaccurate MMEJ DNA repair, and likely contributes to progression to leukemia.
• Moreover, it inhibits DNA repair, causing genomic instability and potentially causing the feared blast crisis in CML.
• Studies show that in cases of cancer and other genomic instability, higher levels of EEs can be observed.
• Field defects associated with gastrointestinal tract cancers also commonly displayed reduced apoptosis competence, aberrant proliferation and genomic instability.
• The result is a proliferation of a plasma cell clone and genomic instability that leads to further mutations and translocations.
• On the cellular level, cells of affected individuals exhibit chromosomal abnormalities, genomic instability, and sensitivity to mutagens.
• She is internationally recognized researcher in the field of gentics of autism spectrum disorder with special focus on genomic instability.
• Telomere shortening causes genomic instability and occurs naturally with advanced age, both factors that correlate with possible causes of cancer.
• Alu elements are known to create genomic instability and affect gene expression, and have been implicated in numerous human diseases.
• Instead, surviving cells appear to have acquired a genomic instability which causes an increased rate of mutations in future generations.
• This mechanism appears to prevent genomic instability and development of cancer in human aged cells by limiting the number of cell divisions.
• Many anticancer therapies, including ionizing radiation and many chemotherapeutics, rely on the overproduction of reactive oxygen species to cause genomic instability.